Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function

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Interactions between the Su(Hw) and Mod(mdg4) proteins required for gypsy insulator function.

The gypsy insulator is thought to play a role in nuclear organization and the establishment of higher order chromatin domains by bringing together several individual insulator sites to form rosette-like structures in the interphase nucleus. The Su(Hw) and Mod(mdg4) proteins are components of the gypsy insulator required for its effect on enhancer-promoter interactions. Using the yeast two-hybri...

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Insulators are DNA-protein complexes that play a central role in chromatin organization and regulation of gene expression. In Drosophila different proteins, dCTCF, Su(Hw), and BEAF bind to specific subsets of insulators most of them having in common CP190. It has been shown that there are a number of CP190-binding sites that are not shared with any other known insulator protein, suggesting that...

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ژورنال

عنوان ژورنال: The EMBO Journal

سال: 2001

ISSN: 1460-2075

DOI: 10.1093/emboj/20.10.2518